SARCOIDOSIS PRODUCING PORTAL HYPERTENSION

Role of thromboxane in producing portal hypertension following trauma-hemorrhage.

Thromboxane A2 (TXA2) and endothelin-1 (ET-1) have been proposed as the important vasoconstrictors that increase portal venous resistance in paracrine or autocrine fashion. We hypothesized that the hepatic damage following trauma-hemorrhage (T-H) is induced by the impaired hepatic circulation due to the increased production of vasoconstrictors such as ET-1 and TXA2 by the liver. To test this, m...

Portal circulation and portal hypertension.

During the last 25 years, there have been important developments in visualising the portal vein, in examining its contents, and in measuring the pressure of blood flowing within it. Radiologists have set the scene and now is the time of the scanner. These technical advances have been applied to the diagnosis and treatment of patients with portal hypertension, and many ingenious surgical techniq...

SURGICAL EXPERIENCE WITH PORTAL HYPERTENSION DUE TO HEPATOPORTAL SCLEROSIS (NONCIRRHOTIC PORTAL FIBROSIS)

Hepatoportal sclerosis or idiopathic portal hypertension has a worldwide distribution with prevalence in developing and temperate countries. Of 64 patients with this disease seen during a twelve year period, 36 underwent splenectomy or a shunt procedure. The indications for surgical intervention were severe hypersplenism and persistent left upper abdominal pain andlorhistory of frequent ep...

Portal Hypertension

Introduction Portal hypertension (PHT) may be caused by a wide variety of conditions, each with a different natural history. It frequently presents with bleeding from oesophageal varices, which is the commonest cause of serious upper gastrointestinal haemorrhage in children. Precise diagnosis, a sound understanding of the therapeutic options, and a multidisciplinary approach are essential for s...

Portal Hypertension